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KMID : 0948320050050020178
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Konyang Medical Journal
2005 Volume.5 No. 2 p.178 ~ p.182
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Association between Serum Soluble E-selectin and Coronary artery Lesions in Kawasaki disease
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Jeong Jae-Ho
Ko Kyong-Og
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Abstract
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Purpose: The aim of this study was to investigate the pathophysiologic role of serum E-selectin, vascular endothelial growth factor (VEGF)-induced cell adhesion mollecule in KD and to look for the evidence of direct relationship between the plasma levels of soluble E-selectin and the incidence of coronary artery lesion (CAL).
Methods: Changes in plasma levels of sE-selectin (n=98) over time were measured by enzyme linked immunosorbent assay (ELISA) in 23 patients with acute KD and 25 age-matched febrile childrens.
Results: Compared with control values, the peak levels of plasma sE-selectin were significantly elevated (mean± S.E.: 22.89±12.53 ng/mL vs 10.65±3.42 ng/mL, P=0.01) in KD. 5 patients with CAL, plasma sE-selectin levels before treatment were higher than in 18 patients without CAL (mean±S.E.: 39.43±15.08 ng/mL and 19.00±8.32 ng/ mL, respectively; P=0.01). Plasma sE-selectin declined rapidly in the majority of KD patients regardless of the presence of CAL. Plasma sE-selectin levels after treatment and convalesent period were similar in KD patients with and without CAL. The plasma levels sE-selectin were correlated with those of white blood cell count (r=0.299, P<0.05), CRP (r=0.430, P<0.05), serum albumin (r=-0.483, P<0.05), serum protein (r=-0.502, P<0.05) and hemoglobin (r=- 0.372, P<0.05) not with those of ESR, platelet, or duration of fever. There were significant differences in the initial level of serum sE-selectin between KD with and without CAL (mean±S.E.: 39.44±15.08 ng/mL vs. 19.00± 17.18 ng/mL) in multivariated linear test.
Conclusion: Plasma sE-selectin levels were significantly higher in KD than other febrile illness. Higher plamsa levels of sE-selectin may have potential as a predictor of CAL in patients with KD.
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KEYWORD
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Kawasaki disease, E-selectin, Coronary artery, Lesion
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